Furfurylamine → N2,N4-bis(furfuryl)-5-fluoro-2,4-pyrimidinediamine

HRID 71393

반응식

[OH:1][C:2]1C=[C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])C=3)[C:12]([F:23])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.ClC1N=C(Cl)C(F)=CN=1.C(N)C1OC=CC=1>>[CH2:4]([NH:8][C:9]1[N:14]=[C:13]([NH:15][CH2:16][C:21]2[O:22][CH:18]=[CH:19][CH:20]=2)[C:12]([F:23])=[CH:11][N:10]=1)[C:5]1[O:1][CH:2]=[CH:7][CH:6]=1

참가 물질

반응물 3

HCID 3438Furfurylamine

HCID 2507052,4-Dichloro-5-fluoropyrimidine

HCID 9904854R-112

생성물 1

HCID 22060499N2,N4-bis(furfuryl)-5-fluoro-2,4-pyrimidinediamine

실험 절차

In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and furfurylamine were reacted to yield N2,N4-bis(furfuryl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.72 (bs, 1H), 7.38 (dd, 2H, J=1.8 and 7.5 Hz), 6.34-6.30 (m, 2H), 6.22 (dd, 2H, J=2.4 and 9.9 Hz), 5.163 (bs, 2H), 4.63 (d, 2H, J=6.0), 4.54 (d, 2H, J=6.0).; 19F NMR (CDCl3): −48621; LCMS: ret. time: 97.27 min.; purity: 97%; MS (m/e): 289 (MH+).

후처리

customwere reacted

출처 및 근거

ORD 기록: ord-ab6a3b997b354cc09b4a0cee938c3187
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08822685B2

연결된 노트

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