Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl chloride → N-benzyl-2-(3-phenylpropanamido)-isonicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 반응물 | Benzenepropanoyl chloride | HCID 64801 | — |
| 반응물 | 2-amino-N-benzylisonicotinamide | HCID 18752897 | — |
| 생성물 | N-benzyl-2-(3-phenylpropanamido)-isonicotinamide | HCID 67153848 | 42% |
반응 단계
Following the procedure as describe in preparation of Example 5, making variations as required to replace benzoyl chloride with hydrocinnamoyl chloride, to react with 2-amino-N-benzylisonicotinamide, N-benzyl-2-(3-phenylpropanamido)-isonicotinamide was obtained in 42% yield: mp 177-179° C.; 1H NMR (300 MHz, CDCl3) δ 10.63 (s, 1H), 9.26 (s, 1H), 8.46-8.36 (m, 2H), 7.54-7.14 (m, 11H), 4.43 (s, 2H), 2.86-2.68 (m, 4H); MS (ES+) m/z 360.6 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09187426B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-208b01bac54d41f5847bf631a0693001 |
| 출처 메모 | uspto-grants-2015_11 |