反应详情

Following the procedure as describe in preparation of Example 5, making variations as required to replace benzoyl chloride with hydrocinnamoyl chloride, to react with 2-amino-N-benzylisonicotinamide, N-benzyl-2-(3-phenylpropanamido)-isonicotinamide was obtained in 42% yield: mp 177-179° C.; 1H NMR (300 MHz, CDCl3) δ 10.63 (s, 1H), 9.26 (s, 1H), 8.46-8.36 (m, 2H), 7.54-7.14 (m, 11H), 4.43 (s, 2H), 2.86-2.68 (m, 4H); MS (ES+) m/z 360.6 (M+1).

1. customas describe in preparation of Example 5