Propylenediamine → HCID 178439575, 화합물

반응식

NCC(N)C.[NH2:6][CH2:7][CH:8]([NH2:12])[CH2:9][CH2:10][CH3:11].[C:13]([NH:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][N:30]=1)[C:25](O)=O)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:9]([CH:8]1[CH2:7][NH:6][C:25]([C:24]2[CH:28]=[CH:29][N:30]=[C:22]([NH:21][C:13](=[O:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:23]=2)=[N:12]1)[CH2:10][CH3:11]

참가 물질

반응물 3

HCID 6567Propylenediamine

HCID 14637946Pentane-1,2-diamine

HCID 643938512-Benzamidoisonicotinic acid

생성물 1

HCID 178439575HCID 178439575, 화합물수율 20%

실험 절차

Following the procedure as described in EXAMPLE 9, making variations as required to replace 1,2-diaminopropane with 1,2-diaminopentane to react with 2-benzamidoisonicotinic acid, N-(4-(4-propyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide was obtained in 20% yield: MS (ES+) m/z 309.4 (M+1).

출처 및 근거

ORD 기록: ord-18a556bf0c4642c5963fc7c97705a842
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09187426B2

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