Hydrochloric Acid → 6-Ethyl-4-hydroxy-3-propanoyl-2H-pyran-2-one

HRID 714435

반응식

HRID 714435 반응식
[O:1]=[C:2]([CH2:7][CH3:8])[CH2:3][C:4]([OH:6])=[O:5].Cl>C1COCC1>[CH2:7]([C:2]1[O:5][C:4](=[O:6])[C:3]([C:2](=[O:1])[CH2:7][CH3:8])=[C:4]([OH:5])[CH:3]=1)[CH3:8]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 4396843-Oxopentanoic acid

생성물 1

HCID 546878366-Ethyl-4-hydroxy-3-propanoyl-2H-pyran-2-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

3-Oxopentanoic acid (II in Scheme 1; Example 1.1; 2 g; 17.2 mmol) was dissolved in 30 ml THF and cooled to 0° C. To the solution, was added dicarbodiimidazole (3.6 g; 22.2 mmol; Aldrich). The reaction mixture was stirred for 18 h at 25° C., neutralized with 2% HCl, extracted with 3×30 ml EtOAc, dried with anhydrous Na2SO4, and evaporated to a white solid. The product was purified via silica chromatography (20% EtOAc in hexanes).

후처리

  1. additionTo the solution, was added dicarbodiimidazole (3.6 g; 22.2 mmol; Aldrich)
  2. extractionextracted with 3×30 ml EtOAc
  3. dry with materialdried with anhydrous Na2SO4
  4. customevaporated to a white solid
  5. customThe product was purified via silica chromatography (20% EtOAc in hexanes)

출처 및 근거

ORD 기록
ord-87569190479a43878ef0475ad79800cb
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187446B2

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