Water → N-(5-Nitro-pyrimidin-2-yl)-benzamide

HRID 714576

반응식

HRID 714576 반응식
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[C:11](Cl)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.O>N1C=CC=CC=1>[C:11]([NH:1][C:2]1[N:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 7412Benzoyl chlorideHCID 764905-Nitropyrimidin-2-amine

생성물 1

HCID 57699955N-(5-Nitro-pyrimidin-2-yl)-benzamide수율 45.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To stirred solution of 2-amino-5-nitropyrimidine (1.0 g, 7.14 mmol) in pyridine (20 ml) was added benzoyl chloride (0.92 ml, 7.93 mmol). The mixture was refluxed for 4 hr under nitrogen atmosphere. The reactant mixture was cooled to the room temperature and poured into 200 ml water. The resulting mixture was stirred overnight and then filtered in vacuo. The filter cake was washed with water (20 ml*3) and dried in vacuo to give 2-(N-benzoyl)amino-5-nitropyrimidine as a white solid (790 mg).

후처리

  1. temperatureThe mixture was refluxed for 4 hr under nitrogen atmosphere
  2. filtrationfiltered in vacuo
  3. washThe filter cake was washed with water (20 ml*3)
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-4703bc90db2a4c779ad15f3d7b8b4ead
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187458B2

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