2,6-Difluorobenzoic acid → Sodium 2,6-difluorobenzoate

HRID 714930노트

반응식

HRID 714930 반응식
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:13]>CCO.O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:13]

참가 물질

5

반응물 2

HCID 97962,6-Difluorobenzoic acidHCID 14798Sodium Hydroxide

생성물 1

HCID 23698872Sodium 2,6-difluorobenzoate수율 100%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of 2,6-difluorobenzoic acid (1.00 g, 6.3 mmol) in EtOH and water (5:1, 60 mL) was added 1N aqueous sodium hydroxide solution (6.33 mL, 6.3 mmol). The reaction mixture was stirred for 10 minutes at room temperature and then solvents were removed in vacuo to yield sodium 2,6-difluorobenzoate (1.22 g, 6.3 mmol, quantitative) as an off white solid. 1H NMR (DMSO) δ 6.89 (2H, m), 7.15 (1H, m).

후처리

  1. customsolvents were removed in vacuo

출처 및 근거

ORD 기록
ord-42caf2d19a924c09b8ec9a72668f2496
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187465B2

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