Methanol → Methyl p-aminosalicylate

HRID 71535

반응식

HRID 71535 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.[CH3:12]O>>[OH:11][C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:12])=[O:7])[NH2:1]

참가 물질

3

반응물 2

HCID 887MethanolHCID 46494-Aminosalicylic Acid

생성물 1

HCID 77787Methyl p-aminosalicylate

실험 절차

A solution of 4-amino-2-hydroxybenzoic acid (1 g, 6.5 mmol) in MeOH (15 mL) and concentrated sulfonic acid (1 mL) was refluxed overnight. The reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL). The organic layer was separated, dried, evaporated to give 3-hydroxy-4-methoxycarbonylaniline.

후처리

  1. customThe reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL)
  2. customThe organic layer was separated
  3. customdried
  4. customevaporated

출처 및 근거

ORD 기록
ord-aba6bdb960ce41dead32062ee1bf5d05
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822685B2

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