Sodium Bicarbonate → 1-(4-Bromophenyl)piperidin-4-ol

HRID 715560노트

반응식

HRID 715560 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[BH4-].[Na+].C([O-])(O)=O.[Na+]>CO>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 4311764Sodium borohydrideHCID 246921481-(4-Bromophenyl)piperidin-4-one

생성물 1

HCID 235052161-(4-Bromophenyl)piperidin-4-ol

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
0 °C

실험 절차

1-(4-Bromophenyl)piperidin-4-one (765 mg) is dissolved under argon in MeOH (8 mL), cooled to 0° C. and treated with NaBH4 (145 mg). The mixture is stirred for 2 hours at 0° C., treated with saturated aqueous NaHCO3 solution and stirred for 10 minutes. Then the mixture is extracted with ethylacetate and the organic phase is washed with brine and dried (MgSO4). The solvents are evaporated to give the title compound. LC (method 2): tR=0.92 min; Mass spectrum (ESI+): m/z=256 [M+H]+.

후처리

  1. stirringstirred for 10 minutes
  2. extractionThen the mixture is extracted with ethylacetate
  3. washthe organic phase is washed with brine
  4. dry with materialdried (MgSO4)
  5. customThe solvents are evaporated

출처 및 근거

ORD 기록
ord-3d95ece6ff234f99847e4c9a3d22fdb0
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187477B2

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