Sodium Hydroxide → HCID 86701047, 화합물
반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]2[N:13]=[C:14]([S:17][CH:18]([CH2:24][CH3:25])[C:19]([O:21]CC)=[O:20])[CH:15]=[CH:16][C:11]2=[N:10][N:9]=1.[OH-].[Na+]>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]2[N:13]=[C:14]([S:17][CH:18]([CH2:24][CH3:25])[C:19]([OH:21])=[O:20])[CH:15]=[CH:16][C:11]2=[N:10][N:9]=1참가 물질
4
실험 절차
To a solution of ethyl 2-((3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanoate (1 mmol) in dioxane (3 mL) was added 0.5 ml of sodium hydroxide (2N), and the reaction mixture was stirred at room temperature. After 2 hours, the mixture was evaporated to dryness, and the obtained residue dissolved in water (2 mL) and then acidified with an hydrochloric acid solution. The resulting precipitate was filtered, washed with water, and dried to give 2-((3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanoic acid.