Hydrochloric Acid → 2,4-Dibromo-N-(4-bromophenyl)butanamide

HRID 715923

반응식

HRID 715923 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[Br:9][CH:10]([CH2:14][CH2:15][Br:16])[C:11](Cl)=[O:12].Cl>ClCCl.C(N(CC)CC)C>[Br:9][CH:10]([CH2:14][CH2:15][Br:16])[C:11]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([Br:1])=[CH:3][CH:4]=1)=[O:12]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 78074-BromoanilineHCID 44131432,4-Dibromobutyryl chloride

생성물 1

HCID 1178748012,4-Dibromo-N-(4-bromophenyl)butanamide

시약·촉매·용매 2

HCID 6344Dichloromethane용매2회HCID 8471Triethylamine용매

실험 절차

To a solution of 4-bromoaniline (1.73 g) in dichloromethane (40 ml), triethylamine (2.8 ml) and a solution of 2,4-dibromobutyryl chloride (3.2 g) in dichloromethane (10 ml) were added under ice cooling, and the mixture was stirred at room temperature for 5 hours. After addition of 1 N hydrochloric acid to the reaction solution, the mixture was separated into two layers. The aqueous layer was subjected to extraction with chloroform. The organic layers were combined, washed with a saturated aqueous solution of sodium bicarbonate and saturated saline in this order and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain a crude product of the title compound, which was used in the next reaction without being purified.

후처리

  1. customthe mixture was separated into two layers
  2. extractionThe aqueous layer was subjected to extraction with chloroform
  3. washwashed with a saturated aqueous solution of sodium bicarbonate and saturated saline in this order
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-8338ee55c374481c9bb6df8e9bdb033b
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187489B2

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