Methyl iodide → (E)-methyl 3-(3-methoxyphenyl)acrylate

HRID 716013노트

반응식

HRID 716013 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[CH:9]=[CH:10]/[C:11]([OH:13])=[O:12])[CH:6]=[CH:7][CH:8]=1.[C:14]([O-])([O-])=O.[K+].[K+].IC>CC(C)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[CH:9]=[CH:10]/[C:11]([O:13][CH3:14])=[O:12])[CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 6376683-Methoxycinnamic Acid

생성물 1

HCID 11041597(E)-methyl 3-(3-methoxyphenyl)acrylate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of (E)-3-(3-methoxyphenyl)acrylic acid (3.56 g, 20 mmol). K2CO3 (3.1 g, 22 mmol), and iodomethane (4.0 g, 28 mmol) in acetone (20 mL) was heated to 70° C. for 16 hours. The mixture was concentrated and partitioned between water and ethyl acetate to afford the crude title compound.

후처리

  1. concentrationThe mixture was concentrated
  2. custompartitioned between water and ethyl acetate

출처 및 근거

ORD 기록
ord-d04f77836ff34219b92b4a1192de63a6
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187483B2

반응 노트

불러오는 중…