HCID 642972, 화합물 → HCID 12728388, 화합물
반응식
[CH3:1][C:2]1[CH2:11][C:6]2([CH2:10][CH2:9][CH2:8][CH2:7]2)[O:5][CH2:4][CH:3]=1.[H][H]>[Ni].[Pd].C(O)(C)C>[CH3:1][CH:2]1[CH2:11][C:6]2([CH2:7][CH2:8][CH2:9][CH2:10]2)[O:5][CH2:4][CH2:3]1참가 물질
6
실험 절차
A solution of 9-methyl-6-oxaspiro[4.5]dec-8-ene (1.52 kg, 10.0 mols), isopropyl alcohol (1000 ml) and Raney nickel (100 g), Pd/C (100 g) or other suitable sponge-metal catalyst was hydrogenated at 450 psi, at 140° C. for 10-12 h until the theoretical amount of hydrogen was taken up. The mixture was cooled and filtrated. The isopropyl alcohol was evaporated and the residue obtained was distilled under reduced pressure to provide 9-methyl-6-oxaspiro[4.5]decane (1.4 kg, yield: 95%, purity: 98%).
후처리
- temperatureThe mixture was cooled
- filtrationfiltrated
- customThe isopropyl alcohol was evaporated
- customthe residue obtained
- distillationwas distilled under reduced pressure
출처 및 근거
- ORD 기록
- ord-eb70911fa5bd4d23b969e97fc3bb020c
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09187709B2
반응 노트
불러오는 중…