Hydrochloric Acid → 2-Bromo-imidazo[2,1-b]thiazol-6-ylamine hydrochloride

HRID 716510노트

반응식

HRID 716510 반응식
[ClH:1].C(OC(=O)[NH:8][C:9]1[N:10]=[C:11]2[N:15]([CH:16]=1)[CH:14]=[C:13]([Br:17])[S:12]2)(C)(C)C>O1CCOCC1>[ClH:1].[Br:17][C:13]1[S:12][C:11]2=[N:10][C:9]([NH2:8])=[CH:16][N:15]2[CH:14]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58310246(2-Bromo-imidazo[2,1-b]thiazol-6-yl)-carbamic acid tert-butyl ester

생성물 1

HCID 672405282-Bromo-imidazo[2,1-b]thiazol-6-ylamine hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of 4M HCl in dioxane (2 mL) was added compound 10 (0.13 mmol). The reaction mixture was stirred at room temperature for 4 hrs. The mixture was concentrated under vacuum and the solid was dried in vacuo to give compound 11 as a white solid in quantitative yield. 1H NMR (CDCl3, 400 MHz) δ (ppm) 5.26 (s, 2H), 8.20 (s, 1H), 9.92 (brs, 1H), 10.05 (brs, 1H); and MS (ESI, EI+) m/z=218.02-220.03 (MH+).

후처리

  1. concentrationThe mixture was concentrated under vacuum
  2. customthe solid was dried in vacuo

출처 및 근거

ORD 기록
ord-0711789064c444e196f6a32a0ab37f0e
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187496B2

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