Diethyl Malonate → Ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

HRID 716687

반응식

HRID 716687 반응식
[CH2:1]([N:8]1[C:14](=[O:15])[O:13][C:11](=O)[C:10]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:9]12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].C(OCC)(=O)[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[CH2:1]([N:8]1[C:9]2[C:10](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:11]([OH:13])=[C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:14]1=[O:15])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 7761Diethyl MalonateHCID 24758Sodium hydrideHCID 520756N-Benzylisatoic anhydride

생성물 1

HCID 54711837Ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

실험 절차

Reagents: Comp 21 (3.4 mmols, 0.85 g); Sodium hydride (7.37 mmols, 0.18 g); Diethyl malonate (16.8 mmols, 2.7 g). Yield: 0.1 g (9%), white solid, m.p.=117° C.-118° C.

출처 및 근거

ORD 기록
ord-4341ae00578d4fe39b764d0e0c4339ed
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193688B2

연결된 노트

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