2-Chlorophenol → 4-Chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine

HRID 716724

반응식

CO/N=C(/C1OCCON=1)\C1C=CC=CC=1O[C:12]1[N:17]=[CH:16][N:15]=[C:14]([O:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:24]=2[Cl:25])[C:13]=1[F:26].[Cl:33]C1C(F)=C(Cl)N=CN=1.ClC1C=CC=CC=1O>>[Cl:33][C:12]1[C:13]([F:26])=[C:14]([O:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:24]=2[Cl:25])[N:15]=[CH:16][N:17]=1

참가 물질

반응물 3

HCID 72452-Chlorophenol

HCID 11048796Fluoxastrobin

HCID 112866754,6-Dichloro-5-fluoropyrimidine

생성물 1

HCID 112306784-Chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine

실험 절차

Fluoxastrobin may further be prepared as described in Scheme 3. Particularly, 4,6-dichloro-5-fluoropyrimidine (5) is reacted with 2-chlorophenol in an appropriate solvent and in the presence of a suitable base to give intermediate 4-chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine (17) which is further reacted with (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime (13) to give fluoxastrobin.

출처 및 근거

ORD 기록: ord-84fc7b85c1d84a1f9a41fab65b5c04d4
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09193698B2

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