Sodium Hydroxide → 3-Chlorophenylglyoxylic acid

HRID 716732노트

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HRID 716732 반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([C:10](=[O:16])[C:11]([O:13]CC)=[O:12])[CH:7]=[CH:8][CH:9]=1>C1COCC1.CO>[Cl:3][C:4]1[CH:5]=[C:6]([C:10](=[O:16])[C:11]([OH:13])=[O:12])[CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 2758814ethyl 2-(3-chlorophenyl)-2-oxoacetate

생성물 1

HCID 122529103-Chlorophenylglyoxylic acid수율 115.2%

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

An aqueous 2 mol/L NaOH solution (24 mL) was added to a solution of ethyl (3-chlorophenyl)(oxo)acetate (2.00 g) in THF/MeOH (1:1) (48 mL) in an ice bath, followed by stirring at room temperature overnight. The solvent was distilled off under reduced pressure, and an aqueous 3 mol/L HCl solution was added thereto in an ice bath. The precipitated solid was collected by filtration to yield the title compound (2.00 g, colorless solid).

후처리

  1. distillationThe solvent was distilled off under reduced pressure
  2. additionan aqueous 3 mol/L HCl solution was added
  3. filtrationThe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-ed40ffaa3da34e729845a2fd9b3e881b
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193695B2

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