Phenethylamine → Formamide, N-(2-phenylethyl)-

HRID 716953

반응식

HRID 716953 반응식
[C:1]1([CH2:7][CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:10](OCC)=[O:11]>>[CH2:8]([NH:9][CH:10]=[O:11])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 1001PhenethylamineHCID 8025Ethyl formate

생성물 1

HCID 140995Formamide, N-(2-phenylethyl)-

반응 조건

온도
50 °C

실험 절차

Into a 100-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed 2-phenylethanamine (1.9 g, 15.70 mmol, 1.00 equiv). This was followed by the addition of ethyl formate (5 g, 67.57 mmol, 4.30 equiv) dropwise with stiffing. The resulting solution was stirred overnight at 50° C. The resulting solution was concentrated under vacuum. The residue was applied onto a silica gel column with dichloromethane/methanol (70:1). This resulted in 2.27 g (97%) of N-phenethylformamide as yellow oil.

후처리

  1. customInto a 100-mL 3-necked round-bottom flask purged
  2. temperaturemaintained with an inert atmosphere of nitrogen
  3. concentrationThe resulting solution was concentrated under vacuum
  4. customThis resulted in 2.27 g (97%) of N-phenethylformamide as yellow oil

출처 및 근거

ORD 기록
ord-3297cd83d6744d5c9fce381b2a37e689
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193693B2

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