Hydrochloric Acid → 4-Fluoro-2-methylcinnamic acid

HRID 717095

반응식

HRID 717095 반응식
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([CH3:10])[CH:3]=1.C(O)(=O)[CH2:12][C:13]([OH:15])=[O:14].N1CCCCC1.Cl>N1C=CC=CC=1>[F:1][C:2]1[CH:9]=[CH:8][C:5](/[CH:6]=[CH:12]/[C:13]([OH:15])=[O:14])=[C:4]([CH3:10])[CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 27832174-Fluoro-2-methylbenzaldehyde

생성물 1

HCID 547757764-Fluoro-2-methylcinnamic acid수율 69%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
70 °C

실험 절차

A stirred solution of 4-fluoro-2-methyl-benzaldehyde (20 g, 144.9 mmol) and malonic acid (30.1 g, 289.8 mmol) in pyridine (100 mL) was heated to 50° C. Piperidine (10 mL) was added and the reaction mixture was heated at 70° C. for 18 h. The reaction mixture was cooled RT and poured into chilled aqueous 1N HCl solution (1500 mL), the resulting precipitate was filtered and washed with petroleum ether 60-80 and dried in vacuo to obtain (E)-3-(4-fluoro-2-methylphenyl)acrylic acid (18 g, 69%) as an off white solid.

후처리

  1. temperatureThe reaction mixture was cooled RT
  2. additionpoured
  3. filtrationthe resulting precipitate was filtered
  4. washwashed with petroleum ether 60-80
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-8f856b60844c4a909a0cce1f822c5b95
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193689B2

연결된 노트

불러오는 중…