Dimethylformamide dimethyl acetal → HCID 178484244, 화합물

HRID 717248

반응식

HRID 717248 반응식
[C:1]([C:5]1[CH:9]=[C:8]([NH2:10])[NH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[C:1]([C:5]1[CH:9]=[C:8](/[N:10]=[CH:13]/[N:14]([CH3:16])[CH3:15])[NH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 178441179HCID 178441179, 화합물

생성물 1

HCID 178484244HCID 178484244, 화합물수율 99%

실험 절차

A mixture of 3-tert-butyl-1H-pyrazol-5-amine (5 g, 36 mmol, Alfa-aesar) and N,N-dimethylformamide dimethylacetal (153 mL, 1078 mmol, Aldrich) was refluxed overnight. The reaction mixture was then cooled, concentrated under reduced pressure and the residue was purified by column chromatography using an Analogix® Intelliflash280™ (SiO2, 0-5% methanol in dichloromethane) to provide 6.9 g (99%) of the title compound. MS (ESI+) m/z 195 (M+H)+.

후처리

  1. temperaturewas refluxed overnight
  2. temperatureThe reaction mixture was then cooled
  3. concentrationconcentrated under reduced pressure
  4. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-c0b873635e024ef7ac056cf6682c5210
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193713B2

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