Lithium Hydroxide → Lithium 4-benzyl-2,5-dioxo-1-[(1R)-1-phenylethyl]imidazolidine-4-carboxylate
반응식
C([O:3][C:4](=[O:30])[C:5]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([NH:11][C:12](=[O:22])[NH:13][C@@H:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:15])[C:6]([O:8]CC)=O)C.[OH-].[Li+:32]>O1CCCC1.CO>[CH2:23]([C:5]1([C:4]([O-:3])=[O:30])[C:6](=[O:8])[N:13]([C@@H:14]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH3:15])[C:12](=[O:22])[NH:11]1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1.[Li+:32]참가 물질
5
실험 절차
To a solution of the product from Step C (7.8 g, 18.91 mmol) in tetrahydrofuran (60 mL) and methanol (20.00 mL) was added a 1 M lithium hydroxide solution (19.86 mL, 19.86 mmol) and the mixture stirred for 30 min. The solvent was removed in vacuo and the residue azeotroped with toluene (3×25 mL) to afford the title compound as a colorless amorphous solid. LC/MS 339.1 (M+1).