Ammonium Chloride → N-(3,4-diaminophenyl)methanesulfonamide

HRID 717320노트

반응식

HRID 717320 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])=[CH:4][C:3]=1[N+:13]([O-])=O.[BH4-].[Na+].[NH4+].[Cl-]>CO.CCOC(C)=O.[Pd]>[NH2:13][C:3]1[CH:4]=[C:5]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:6]=[CH:7][C:2]=1[NH2:1]

참가 물질

6

반응물 3

HCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 1270965376345-45-4

생성물 1

HCID 12709656N-(3,4-diaminophenyl)methanesulfonamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21584119Ethylacetate methanol용매

실험 절차

N-(4-amino-3-nitrophenyl)methanesulfonamide (1.5 g, 6.5 mmol) was dissolved in MeOH/EtOAc(1:1, 160 mL). To the above solution were slowly added 10% Pd/C (110 mg) and NaBH4 (418 mg, 11.0 mmol). The reaction mixture was stirred for 1 h, after which TLC showed absence of starting material. After addition of NH4Cl (400 mg), the reaction mixture was filtered through CELITE. The filtrate was concentrated and the product was used without further purification.

후처리

  1. filtrationthe reaction mixture was filtered through CELITE
  2. concentrationThe filtrate was concentrated
  3. customthe product was used without further purification

출처 및 근거

ORD 기록
ord-3684ccedc0ff439f945a34825669fedc
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193717B2

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