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[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8](I)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[C:12]([C:14]1[O:15][C:16]2[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:17]=2[CH:18]=1)#[CH:13].BrC1C=CC(S(NC2CCC3CC2C3(C)C)(=O)=O)=CC=1.C(O)CC#C>>[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:13]#[C:12][C:14]2[O:15][C:16]3[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:17]=3[CH:18]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]참가 물질
5
실험 절차
When 4-iodophenyl acetate and 2-ethynyl-6-methoxybenzofuran were substituted for 4-bromo-N-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)benzene sulphonamide and but-3-yn-1-ol respectively in Example 18, Step B, the similar process afforded the title compound in 56% yield, as creamy paste. 1H-NMR (CDCl3) 7.56 (d, 2H, J=8.67 Hz); 7.41 (d, 1H, J=8.58 Hz); 7.10 (d, 2H, J=8.7 Hz); 6.97 (d, 1H, J=1.92 Hz); 6.9 (s, 1H); 6.88 (bd, 1H, J=8.61 Hz); 3.85 (s, 3H); 2.3 (s, 3H).
출처 및 근거
- ORD 기록
- ord-ca28b73949ec42c2b97f4887a6cd9d3a
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09193716B2
연결된 노트
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