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3-Phenyl-3,4-dihydroquinoxalin-2(1H)-one → 3,4-dihydro-4-nitroso-3-phenylquinoxalin-2(1H)-one

HRID 717766
노트
인쇄 미리보기

반응식

HRID 717766 반응식
[C:1]1([CH:7]2[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:18]([O-])=[O:19].[Na+]>Cl.O>[N:18]([N:16]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][C:8](=[O:17])[CH:7]1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:19]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 126318403-Phenyl-3,4-dihydroquinoxalin-2(1H)-oneHCID 23668193Sodium Nitrite

생성물 1

HCID 866919253,4-dihydro-4-nitroso-3-phenylquinoxalin-2(1H)-one수율 98.7%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

반응 조건

온도
5 °C

실험 절차

A suspension of 3,4-dihydro-3-phenylquinoxalin-2(1H)-one (430 mg, 1.9 mmol) in 3N HCl (30 mL) was stirred at 5° C. Sodium nitrite (150 mg, 2.17 mmol) in water (1 mL) was added dropwise and stirring was continued for 1 h. The reaction mixture was extracted with DCM. The organic layer was dried over sodium sulfate and concentrated under vacuum to obtain 475 mg of 3,4-dihydro-4-nitroso-3-phenylquinoxalin-2(1H)-one.

후처리

  1. stirringstirring
  2. extractionThe reaction mixture was extracted with DCM
  3. dry with materialThe organic layer was dried over sodium sulfate
  4. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-4910e04cf3554487954978c388293052
출처 데이터셋
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09193728B2

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