5-Methylindoline → 5-Methyl-1-nitrosoindoline
반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH2:6][CH2:5]2.[N:11]([O-])=[O:12].[Na+]>Cl.O>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([N:11]=[O:12])[CH2:6][CH2:5]2참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
5-Methylindoline (1.0 g, 7.5 mmol) was stirred in 3N HCl (20 mL) at 0° C. Sodium nitrite (0.621 g, 9.0 mmol) in water (2 mL) was added dropwise and the mixture was stirred at 0° C. for 5 min. followed by RT for 20 min. The reaction mixture was extracted with DCM (500 mL), and the organic layer was dried over sodium sulfate and concentrated under vacuum to obtain 1.2 g of 5-methyl-1-nitrosoindoline.
후처리
- waitfollowed by RT for 20 min
- extractionThe reaction mixture was extracted with DCM (500 mL)
- dry with materialthe organic layer was dried over sodium sulfate
- concentrationconcentrated under vacuum
출처 및 근거
- ORD 기록
- ord-87962a4fe92a449ba21dd06f782d09e1
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09193728B2
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