5-Methylindoline → HCID 20231382, 화합물

HRID 717782

반응식

HRID 717782 반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH2:6][CH2:5]2.[N:11]([O-])=[O:12].[Na+]>Cl.O>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([N:11]=[O:12])[CH2:6][CH2:5]2

참가 물질

5

반응물 2

HCID 140236795-MethylindolineHCID 23668193Sodium Nitrite

생성물 1

HCID 20231382HCID 20231382, 화합물수율 98.7%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

5-Methylindoline (1.0 g, 7.5 mmol) was stirred in 3N HCl (20 mL) at 0° C. Sodium nitrite (0.621 g, 9.0 mmol) in water (2 mL) was added dropwise and the mixture was stirred at 0° C. for 5 min. followed by RT for 20 min. The reaction mixture was extracted with DCM (500 mL), and the organic layer was dried over sodium sulfate and concentrated under vacuum to obtain 1.2 g of 5-methyl-1-nitrosoindoline.

후처리

  1. waitfollowed by RT for 20 min
  2. extractionThe reaction mixture was extracted with DCM (500 mL)
  3. dry with materialthe organic layer was dried over sodium sulfate
  4. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-87962a4fe92a449ba21dd06f782d09e1
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193728B2

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