3-(4-Fluorophenoxy)propionic acid → Dimethyl 2-(3-(4-fluorophenoxy)propanamido)malonate

HRID 718221

반응식

HRID 718221 반응식
[NH2:1][CH:2]([C:7]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4].[F:11][C:12]1[CH:23]=[CH:22][C:15]([O:16][CH2:17][CH2:18][C:19](O)=[O:20])=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:23]=[CH:22][C:15]([O:16][CH2:17][CH2:18][C:19]([NH:1][CH:2]([C:7]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4])=[O:20])=[CH:14][CH:13]=1

참가 물질

3

반응물 2

HCID 740993-(4-Fluorophenoxy)propionic acidHCID 437601Dimethyl aminomalonate hydrochloride

생성물 1

HCID 50941576Dimethyl 2-(3-(4-fluorophenoxy)propanamido)malonate수율 80%

실험 절차

This compound was synthesized from dimethyl aminomalonate according to the procedure for the preparation of example 2 using 3-(4-fluorophenoxy)propionic acid. The crude residue was purified by flash chromatography on silica (CH2Cl2/MeOH 50:1) to yield the title compound as a white solid (80%).

후처리

  1. customThe crude residue was purified by flash chromatography on silica (CH2Cl2/MeOH 50:1)

출처 및 근거

ORD 기록
ord-8cb18608e0f94394af6f322bdd1a3d92
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193741B2

연결된 노트

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