N-bromobutanimide → 6-(Bromomethyl)phenanthridine

HRID 718738노트

반응식

HRID 718738 반응식
[Br:1]N1C(=O)CCC1=O.[CH3:9][C:10]1[N:11]=[C:12]2[C:17](=[C:18]3[C:23]=1[CH:22]=[CH:21][CH:20]=[CH:19]3)[CH:16]=[CH:15][CH:14]=[CH:13]2>C1C=CC=CC=1>[Br:1][CH2:9][C:10]1[N:11]=[C:12]2[C:17](=[C:18]3[C:23]=1[CH:22]=[CH:21][CH:20]=[CH:19]3)[CH:16]=[CH:15][CH:14]=[CH:13]2

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 3179886-Methylphenanthridine

생성물 1

HCID 856742386-(Bromomethyl)phenanthridine수율 87.1%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

N-bromosuccinimide (557 mg, 3.13 mmol) was added to a solution of the phenanthridine 5 (403 mg, 2.09 mmol) in benzene (20 mL) and the reaction mixture was stirred while lit with a tungsten lamp (150 W) for 45 minutes. The reaction crude, including precipitated succinimide, was deposited onto silica and purified by flash chromatography eluting with CH2Cl2. Evaporation of the solvent under reduced pressure yielded the bromo 6 as a white solid (495 mg, 87.1%).

후처리

  1. customThe reaction crude
  2. customincluding precipitated succinimide
  3. custompurified by flash chromatography
  4. washeluting with CH2Cl2
  5. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-4db0c1c2e10e4417a053660a0e858854
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09194802B2

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