1,4-Dibromobutane → HCID 21896329, 화합물

HRID 719064노트

반응식

HRID 719064 반응식
[Mg].Br[CH2:3][CH2:4][CH2:5][CH2:6]Br.[O:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]([O:15]CC)=O.[Cl-].[NH4+]>O1CCCC1>[O:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]1([OH:15])[CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

6

반응물 4

HCID 80561,4-DibromobutaneHCID 25517Ammonium ChlorideHCID 5462224MagnesiumHCID 101032862-Furancarboxylic acid, tetrahydro-, ethyl ester

생성물 1

HCID 21896329HCID 21896329, 화합물수율 89.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
60 °C

실험 절차

A flask was charged with 13.6 g of magnesium and 300 ml of tetrahydrofuran, to which 60.3 g of 1,4-dibromobutane was added dropwise at 50° C. After the completion of dropwise addition, the solution was stirred at 60° C. for one hour. To the solution below 40° C., 31.0 g of ethyl tetrahydrofurancarboxylate was added dropwise. The solution was stirred at room temperature for one hour, after which an aqueous solution of ammonium chloride was added for hydrolysis. Ordinary post-treatment yielded 30.2 g of 1-(2-tetrahydrofuranyl)cyclopentanol.

후처리

  1. additionwas added dropwise at 50° C
  2. additionAfter the completion of dropwise addition
  3. stirringThe solution was stirred at room temperature for one hour

출처 및 근거

ORD 기록
ord-11ceea0086bb4303ad4a745dd0285ed8
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07132215B2

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