Water → 3-Biphenylylacetic acid

HRID 719592

반응식

HRID 719592 반응식
O.O.[OH-].[Li+].C[O:6][C:7](=[O:21])[CH2:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:12]=[CH:13][CH:14]=1>CO>[C:11]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:12]=[CH:13][CH:14]=[C:9]([CH2:8][C:7]([OH:21])=[O:6])[CH:10]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 10751722Biphenyl-3-ylacetic acid methyl ester

생성물 1

HCID 321533-Biphenylylacetic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Water (39 mL), followed by lithium hydroxide monohydrate (4.2 g, 101.5 mmol) were added to a solution of biphenyl-3-yl acetic acid methyl ester (11.43 g, 50.57 mmol) in methanol (265 mL). The mixture was stirred at ambient temperature for 2h then the organics were removed under reduced pressure. The mixture was acidified with dilute hydrochloric acid (1M, 80 mL), extracted with chloroform (2×100 mL), dried (MgSO4) and evaporated under reduced pressure to afford biphenyl-3-yl acetic acid as a white solid, yield 10.6 g, (99%), analytical HPLC Rt=16.565 min, HPLC-MS (single main UV peak with Rt=7.91 min, 213.1 [M+H]+).

후처리

  1. customthe organics were removed under reduced pressure
  2. extractionextracted with chloroform (2×100 mL)
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-5cbd748ebe3442bda3eabd2bd33eea59
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07132449B2

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