Hydrochloric Acid → (2r)-2-Amino-3-naphthalen-2-yl-n-(6-oxo-2-phenyl-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)propanamide hydrochloride

HRID 720142

반응식

HRID 720142 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C@@H:12]([NH:36]C(=O)OC(C)(C)C)[C:13](=[O:35])[NH:14][C:15]1[CH:16]=[C:17]2[C:33](=[O:34])[NH:32][N:31]=[CH:30][C:19]3=[C:20]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[NH:21][C:22]([CH:23]=1)=[C:18]23.[ClH:44]>O1CCOCC1>[ClH:44].[NH2:36][C@H:12]([CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[C:13]([NH:14][C:15]1[CH:16]=[C:17]2[C:33](=[O:34])[NH:32][N:31]=[CH:30][C:19]3=[C:20]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[NH:21][C:22]([CH:23]=1)=[C:18]23)=[O:35]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 1361816471,1-Dimethylethyl (1R)-1-(naphthalen-2-ylmethyl)-2-oxo-2-[(6-oxo-2-phenyl-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)amino]ethylcarbamate

생성물 1

HCID 136401960(2r)-2-Amino-3-naphthalen-2-yl-n-(6-oxo-2-phenyl-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)propanamide hydrochloride수율 99%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Preparation of example 176 from the title compound of Example 154 (59 mg, 0.103 mmol) and 4M HCl in dioxane (10 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner afforded the title compound (52 mg, 0.102 mmol) as an orange/yellow powder in 99% yield.

출처 및 근거

ORD 기록
ord-c0c9a3ecd632422aa85fe7df93b505c4
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07132533B2

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