Thionyl Chloride → 2-Chloromethyl-5,6,7-trimethoxynaphthalene

HRID 720303노트

반응식

HRID 720303 반응식
O[CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([O:17][CH3:18])=[C:8]([O:15][CH3:16])[C:9]=2[O:13][CH3:14])[CH:4]=1.S(Cl)([Cl:21])=O.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl>[Cl:21][CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([O:17][CH3:18])=[C:8]([O:15][CH3:16])[C:9]=2[O:13][CH3:14])[CH:4]=1

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 218915782-Hydroxymethyl-5,6,7-trimethoxynaphthalene

생성물 1

HCID 218916422-Chloromethyl-5,6,7-trimethoxynaphthalene

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

2-Hydroxymethyl-5,6,7-trimethoxynaphthalene (781 mg) was dissolved in chloroform (6 mL), and thionyl chloride (561 mL) was added dropwise to the solution. After stirring at room temperature for 5 hours, the reaction mixture was poured into ice water, and sodium hydrogencarbonate was added to adjust the pH of the reaction mixture to 8 to conduct extraction with ethyl acetate. The resultant organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to obtain the title compound.

후처리

  1. additionwas added
  2. extractionextraction with ethyl acetate
  3. washThe resultant organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-55f8372451644e1b8dd629ed599d8b66
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135473B2

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