Ammonium formate → 1-Azetidin-3-ylmethyl-6-fluoro-1H-indole

HRID 720391노트

반응식

HRID 720391 반응식
C([N:14]1[CH2:17][CH:16]([CH2:18][N:19]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([F:28])[CH:26]=3)[CH:21]=[CH:20]2)[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd].C(O)C>[NH:14]1[CH2:17][CH:16]([CH2:18][N:19]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([F:28])[CH:26]=3)[CH:21]=[CH:20]2)[CH2:15]1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 692042621-(1-benzhydryl-azetidin-3-ylmethyl)-6-fluoro-1H-indole

생성물 1

HCID 218920951-Azetidin-3-ylmethyl-6-fluoro-1H-indole

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 1-(1-benzhydryl-azetidin-3-ylmethyl)-6-fluoro-1H-indole (0.6 g, 1.6 mmol), palladium on carbon (10%, cat.amount) and ammonium formate (0.2 g, 3.2 mmol) in ethanol (20 mL) was refluxed for 30 min. The mixture was filtered through celite and the solvent removed under vacuum. Diphenylmethane was removed by triturating the residue with ether, methylene chloride and decanting. The remaining product was dried under vacuum. The crude material was directly used in next step without further purification.

후처리

  1. temperaturewas refluxed for 30 min
  2. filtrationThe mixture was filtered through celite
  3. customthe solvent removed under vacuum
  4. customDiphenylmethane was removed
  5. customby triturating the residue with ether, methylene chloride
  6. customdecanting
  7. customThe remaining product was dried under vacuum
  8. customThe crude material was directly used in next step without further purification

출처 및 근거

ORD 기록
ord-82e8dae6fdae43dc84e9dd76f8e83df3
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135479B2

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