Sodium Hydroxide → HCID 21891739, 화합물
반응식
C[O:2][C:3]([C:5]1[C:9]([NH:10][C:11](=[O:13])[CH3:12])=[CH:8][S:7][C:6]=1[CH3:14])=[O:4].[OH-].[Na+]>CO>[C:11]([NH:10][C:9]1[C:5]([C:3]([OH:4])=[O:2])=[C:6]([CH3:14])[S:7][CH:8]=1)(=[O:13])[CH3:12]참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
A mixture of 4-acetylamino-2-methyl-thiophene-3-carboxylic acid methyl ester (250 mg, 1.17 mmol) in methanol (4.0 mL) at 25° C. was treated with a 1N aqueous sodium hydroxide solution (3.5 mL, 3.51 mmol). The reaction was stirred at 25° C. for 28 h. At this time, the reaction was concentrated in vacuo, diluted with water (15 mL), and then acidified to pH=2 by the addition of a 1N aqueous hydrochloric acid solution. The resulting slurry was cooled to 0° C. The solid was collected by filtration, washed with water, and the dried in vacuo to afford 4-acetylamino-2-methyl-thiophene-3-carboxylic acid (212 mg, 90.9%) as a tan solid: LR-MS for C8H9NO3 (M−H)+ at m/z=198.