1-Bromo-4-nitrobenzene → 4-Methoxy-4'-nitrobiphenyl

반응식

[N+:1]([C:4]1[CH:9]=[CH:8][C:7](Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:16]2[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

반응물 2

HCID 114661-Bromo-4-nitrobenzene

HCID 201262(4-Methoxyphenyl)boronic acid

생성물 1

HCID 111280794-Methoxy-4'-nitrobiphenyl수율 91%

실험 절차

From 4-nitro-bromobenzene and 4-methoxyphenyl boronic acid, yield 91%; mp 104-105° C. (lit.,3 106-107° C.); IR: 1597, 1509, 1342 and 125I; 1H NMR (600 MHz; CDCl3): 8.27 (2H, d, J 9), 7.69 (2H, d, J 8.4), 7.58 (2H, d, J 9), 7.02 (2H, d, J 8.4) and 3.87 (3 H, s); 13C NMR (CDCl3): 160.4, 147.1, 146.5, 131, 128.5, 127, 124.1, 114.6 and 55.4; m/z (EI) 229 (25%, M+), 169. (30), 131 (30) and 69 (100)(Found: M+, 229.073. C13H11NO3 requires M, 184.074).

후처리

custommp 104-105° C. (lit.,3 106-107° C.)

출처 및 근거

ORD 기록: ord-abd08cf4e519411992d4959947452920
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08828902B2

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