m-Iodobenzenesulphonyl chloride → N2-[(3-Iodophenyl)sulfonyl]glycinamide

HRID 720843노트

반응식

HRID 720843 반응식
[I:1][C:2]1[CH:3]=[C:4]([S:8](Cl)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.Cl.[NH2:13][CH2:14][C:15]([NH2:17])=[O:16].C(N(C(C)C)CC)(C)C>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([S:8]([NH:13][CH2:14][C:15]([NH2:17])=[O:16])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 39766m-Iodobenzenesulphonyl chlorideHCID 81531DiisopropylethylamineHCID 2723639Glycinamide hydrochloride

생성물 1

HCID 21895595N2-[(3-Iodophenyl)sulfonyl]glycinamide수율 42.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

(3-Iodophenyl)sulphonyl chloride (0.303 g) was stirred with glycinamide hydrochloride (0.122 g) and diisopropylethylamine (0.3 ml) in DMF (4 ml) at 21° for 24 h. The mixture was evaporated to dryness and applied to a silica Bond Elut Cartridge (10 g). The cartridge was eluted with CH2Cl2, Et2O and EtOAc. This gave the title compound (0.146 g), LCMS RT=2.36 min, ES+ve 341 (MH)+

후처리

  1. customThe mixture was evaporated to dryness
  2. washThe cartridge was eluted with CH2Cl2, Et2O and EtOAc

출처 및 근거

ORD 기록
ord-3d0845533be24f6daf53f50064bfd17a
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135600B2

반응 노트

불러오는 중…