4-Bromoanisole → 1-(4'-Methoxy(1,1'-biphenyl)-4-yl)ethanone

반응식

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](Br)=[CH:5][CH:4]=1.[C:10]([C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1)(=[O:12])[CH3:11]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:16]2[CH:17]=[CH:18][C:13]([C:10](=[O:12])[CH3:11])=[CH:14][CH:15]=2)=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 77304-Bromoanisole

HCID 37021224-Acetylphenylboronic acid

생성물 1

HCID 3015571-(4'-Methoxy(1,1'-biphenyl)-4-yl)ethanone수율 84%

실험 절차

From 4-methoxy-bromobenzene and 4-acetylphenyl boronic acid, yield 84%; mp 150-151° C. (lit.,5 153-154° C.); IR: 1676, 1602, 1456 and 1236; 1H NMR (400 MHz; CDCl3): 8.01 (2H, d, J 8.4), 7.64 (2H, d, J 8.3), 7.58 (2H, d, J 8.8), 7 (2H, d, J 8.5), 3.86 (3H, s) and 2.62 (3H, s); 13C NMR (CDCl3): 197.6, 159.9, 145.3, 135.3, 132.2, 128.9, 128.3, 126.5, 114.4, 55.3 and 26.5; m/z (EI) 226 (80%, M+), 211 (100) and 69 (60)(Found: M+, 226.099. C15H14O2 requires M, 226.099).

후처리

custommp 150-151° C. (lit.,5 153-154° C.)

출처 및 근거

ORD 기록: ord-835e09acd3e34d54ad32b448e5dc62c0
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08828902B2

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