1-Bromo-4-nitrobenzene → Ethanone, 1-(4'-nitro[1,1'-biphenyl]-4-yl)-

반응식

[N+:1]([C:4]1[CH:9]=[CH:8][C:7](Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:11]([C:14]1[CH:19]=[CH:18][C:17](B(O)O)=[CH:16][CH:15]=1)(=[O:13])[CH3:12]>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:17]2[CH:18]=[CH:19][C:14]([C:11](=[O:13])[CH3:12])=[CH:15][CH:16]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

반응물 2

HCID 114661-Bromo-4-nitrobenzene

HCID 37021224-Acetylphenylboronic acid

생성물 1

HCID 8676Ethanone, 1-(4'-nitro[1,1'-biphenyl]-4-yl)-수율 97%

실험 절차

From 4-nitro-bromobenzene and 4-acetylphenyl boronic acid, yield 97%; mp 144-146° C. (lit.,7 150-151° C.); IR: 1681, 1530, 1497, 1361 and 1280; 1H NMR (400 MHz; CDCl3): 8.02 (2H, d, J 8.5), 7.64-7.56 (4H, m), 7.16 (2H, t, J 8.5) and 2.63 (3H, s); 13C NMR (CDCl3): 197.5, 164.2, 144.7, 136, 128.9, 127, 116, 115.7 and 26.6; m/z (EI) 199 (30%, M+−C2H2O), 131 (50) and 69 (100)(Found: M+−C2H2O, 199.062).

후처리

custommp 144-146° C. (lit.,7 150-151° C.)

출처 및 근거

ORD 기록: ord-333ac6e4e9aa4208bd8f5b2a462024ad
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08828902B2

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