Sodium Hydroxide → 3-(2-{[(Tert-butoxy)carbonyl]amino}acetamido)propanoic acid

HRID 720935

반응식

HRID 720935 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]([O:17]CC)=[O:16])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 21893946Ethyl 3-(2-{(tert-butoxycarbonyl)amino}acetylamino)propionate

생성물 1

HCID 218938843-(2-{[(Tert-butoxy)carbonyl]amino}acetamido)propanoic acid수율 16%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of (6) at 0° C. (3.43 g; 0.012 mmol) in methanol (40 ml) was treated with 2N sodium hydroxide (6.9 ml; 0.013 mmol). The mixture was stirred at ambient temperature for 90 minutes. After evaporation of the methanol and removal of the insoluble material by filtration, the solution was adjusted to pH5 with 6N hydrochloric acid. The mixture was extracted with dichloromethane and the organic layer evaporated to dryness to give 3-[(2-tertbutoxycarbonylaminoacetyl)amino]propanoic acid (7).

후처리

  1. customAfter evaporation of the methanol and removal of the insoluble material
  2. filtrationby filtration
  3. extractionThe mixture was extracted with dichloromethane
  4. customthe organic layer evaporated to dryness

출처 및 근거

ORD 기록
ord-47c9c7199684463cb7fc161e44a736b1
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135502B1

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