Hydrochloric Acid → HCID 178487951, 화합물

HRID 72110노트

반응식

HRID 72110 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8](O)[C:7]([OH:14])=[N:6]2.O=S(Cl)[Cl:17].Cl>CN(C=O)C>[Cl:17][C:8]1[C:7]([OH:14])=[N:6][C:5]2[C:10]([N:9]=1)=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 178488026HCID 178488026, 화합물

생성물 1

HCID 178487951HCID 178487951, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
110 °C

실험 절차

A solution (1.53M) of the product of step 1 in DMF was treated with SOCl2 (1 eq) and heated at 110° C. After 1.5 hours, the reaction mixture was cooled and poured into aqueous HCl (1 N). The resulting precipitate was filtered and washed with H2O and Et2O. The dried solid contained predominantly the title compound as a mixture with 6-methoxyquinoxaline-2,3-diol and 2,3-dichloro-6-methoxyquinoxaline. This material was used directly in the subsequent step. MS (ES+) m/z 211 (M+H)+

후처리

  1. temperaturethe reaction mixture was cooled
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with H2O and Et2O

출처 및 근거

ORD 기록
ord-46399fd1ef554210ba561c81975c26b7
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828930B2

반응 노트

불러오는 중…