Potassium Iodide → 1-(6-Chlorobenzotriazol-1-yl)-propan-2-one

HRID 7216

반응식

HRID 7216 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]2[NH:6][N:7]=[N:8][C:4]=2[CH:3]=1.Cl[CH2:12][C:13](=[O:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]([CH2:12][C:13](=[O:15])[CH3:14])[N:7]=[N:8][C:4]=2[CH:3]=1.[Cl:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[N:7][N:8]([CH2:12][C:13](=[O:15])[CH3:14])[C:4]=2[CH:3]=1

참가 물질

7

반응물 4

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 11430Potassium CarbonateHCID 178418767HCID 178418767, 화합물

생성물 2

HCID 220202521-(6-Chlorobenzotriazol-1-yl)-propan-2-oneHCID 220202531-(5-Chlorobenzotriazol-1-yl)-propan-2-one

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 5 g of 5-chlorobenzotriazole, 1.4 g of chloroacetone, 5.1 g of potassium carbonate and 0.5 g of potassium iodide is stirred into 50 ml of acetone at room temperature for 48 h. The mixture is subsequently filtered, the filtrate concentrated by evaporation in a vacuum, and the residue purified by flash chromatography. In this way, two isomeric products, 1-(5-chlorobenzotriazol-1-yl)-propan-2-one and 1-(6-chlorobenzotriazol-1-yl)-propan-2-one, are isolated in approximately the same quantities, the first of which is then used directly in the next step.

후처리

  1. filtrationThe mixture is subsequently filtered
  2. concentrationthe filtrate concentrated by evaporation in a vacuum
  3. customthe residue purified by flash chromatography

출처 및 근거

ORD 기록
ord-1afeb603539e4cb68b366cc59118d27f
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084280B2

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