Potassium Carbonate → Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

HRID 72194

반응식

HRID 72194 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=1.[CH3:12][N:13]([CH3:19])[CH:14]1[CH2:18][CH2:17][NH:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:12][N:13]([CH3:19])[CH:14]1[CH2:18][CH2:17][N:16]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=2)[CH2:15]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 949565-Fluoro-2-nitrotolueneHCID 27585193-(Dimethylamino)pyrrolidine

생성물 1

HCID 68977058Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4-fluoro-2-methyl-1-nitrobenzene (13.6 g), dimethylpyrrolidin-3-ylamine (10.0 g), potassium carbonate (12 g) and DMF (100 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way; MS (ESI): 250 (M+H+).

후처리

  1. customThe reaction mixture was partitioned between water and ethyl acetate
  2. customThe organic phase was dried
  3. concentrationconcentrated
  4. customThe product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way

출처 및 근거

ORD 기록
ord-0875dc4f41854179839123d1593d5957
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828991B2

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