Dimethylformamide → 4-Butoxy-1-methyl-2-nitrobenzene
반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH2:12](Br)[CH2:13][CH2:14][CH3:15].C(=O)([O-])[O-].[Na+].[Na+].CN(C=O)C>CC(OC)(C)C>[CH2:12]([O:8][C:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)[CH2:13][CH2:14][CH3:15]참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of 4-methyl-3-nitrophenol (10.0 g), butyl bromide (9.4 g), sodium carbonate (6.9 g) and DMF (50 mL) was heated at 80° C. for 7 hours. The cooled reaction solution was diluted with MTBE and washed twice each with water and sodium hydroxide solution. The organic phase was dried and concentrated. The product with the molecular weight of 209.25 (C11H15NO3) was obtained in this way; MS (ESI): 210 (M+H+).
후처리
- customThe cooled reaction solution
- washwashed twice each with water and sodium hydroxide solution
- customThe organic phase was dried
- concentrationconcentrated
- customThe product with the molecular weight of 209.25 (C11H15NO3) was obtained in this way
출처 및 근거
- ORD 기록
- ord-b54f415575cc437c907cf99427af312b
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08828991B2
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