Dimethylformamide → 4-Butoxy-1-methyl-2-nitrobenzene

HRID 72196

반응식

HRID 72196 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH2:12](Br)[CH2:13][CH2:14][CH3:15].C(=O)([O-])[O-].[Na+].[Na+].CN(C=O)C>CC(OC)(C)C>[CH2:12]([O:8][C:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)[CH2:13][CH2:14][CH3:15]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 8002Butyl bromideHCID 10340Sodium CarbonateHCID 162713-Nitro-p-cresol

생성물 1

HCID 689772014-Butoxy-1-methyl-2-nitrobenzene

시약·촉매·용매 1

HCID 15413tert-Butyl methyl ether용매

반응 조건

온도
80 °C

실험 절차

A mixture of 4-methyl-3-nitrophenol (10.0 g), butyl bromide (9.4 g), sodium carbonate (6.9 g) and DMF (50 mL) was heated at 80° C. for 7 hours. The cooled reaction solution was diluted with MTBE and washed twice each with water and sodium hydroxide solution. The organic phase was dried and concentrated. The product with the molecular weight of 209.25 (C11H15NO3) was obtained in this way; MS (ESI): 210 (M+H+).

후처리

  1. customThe cooled reaction solution
  2. washwashed twice each with water and sodium hydroxide solution
  3. customThe organic phase was dried
  4. concentrationconcentrated
  5. customThe product with the molecular weight of 209.25 (C11H15NO3) was obtained in this way

출처 및 근거

ORD 기록
ord-b54f415575cc437c907cf99427af312b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828991B2

연결된 노트

불러오는 중…