Dimethylformamide dimethyl acetal → 2-[(Dimethylamino)methylene]-5,5-dimethylcyclopentanone

HRID 721983

반응식

HRID 721983 반응식
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[CH3:9][C:10]1([CH3:16])[CH2:14][CH2:13][CH2:12][C:11]1=[O:15]>>[CH3:6][N:4]([CH:3]=[C:12]1[CH2:13][CH2:14][C:10]([CH3:16])([CH3:9])[C:11]1=[O:15])[CH3:5]

참가 물질

3

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 1382862,2-Dimethylcyclopentanone

생성물 1

HCID 695835902-[(Dimethylamino)methylene]-5,5-dimethylcyclopentanone수율 83%

실험 절차

A mixture of N,N-dimethylformamide dimethyl acetal (67 mL, 503 mmol) and 2,2-dimethylcyclopentanone (10 g, 90 mmol) was heated at reflux for 2 days. The reaction mixture was then cooled down to room temperature and concentrated. Water (˜380 mL) was added to the residue, and the resulting solution was extracted with methylene chloride. The organic layer was separated, dried over MgSO4 and concentrated to give the title compound (12.5 g) as a yellow-orange oil.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 2 days
  3. concentrationconcentrated
  4. additionWater (˜380 mL) was added to the residue
  5. extractionthe resulting solution was extracted with methylene chloride
  6. customThe organic layer was separated
  7. dry with materialdried over MgSO4
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1228a11e329049219729c13590d0d8db
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138361B2

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