Benzoyl Peroxide → 2-(Bromomethyl)-7-chloro-1,3-benzothiazole
반응식
[Cl:1][C:2]1[C:10]2[S:9][C:8]([CH3:11])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:12][CH2:11][C:8]1[S:9][C:10]2[C:2]([Cl:1])=[CH:3][CH:4]=[CH:5][C:6]=2[N:7]=1참가 물질
5
실험 절차
A mixture of 7-chloro-2-methyl-benzothiazole (1.00 g, 5.45 mmol), N-bromosuccinimide (1.26 g, 7.08 mmol), benzoyl peroxide (0.1 g), and CCl4 (10 mL was heated to reflux under irradiation of a UV lamp for 14 h. The reaction mixture was cooled and filtered to remove the succinimide formed in the reaction, and the filtrate was evaporated to dryness. The resulting solid was purified by flash chromatography to give the title lamp (400 mg, 1.5 mmol). 1H-NMR (CDCl3): δ 7.94 (d, 1H), 7.47 (t, 1H), 7.42 (d, 1H), 4.82 (s, 2H, CH2). HPLC Rt: 7.19 min.
후처리
- temperaturewas heated
- temperatureto reflux under irradiation of a UV lamp for 14 h
- temperatureThe reaction mixture was cooled
- filtrationfiltered
- customto remove the succinimide
- customformed in the reaction
- customthe filtrate was evaporated to dryness
- customThe resulting solid was purified by flash chromatography
- customto give the title lamp (400 mg, 1.5 mmol)
출처 및 근거
- ORD 기록
- ord-a139d2f85fc1428581b4d72518d71dd6
- 출처 데이터셋
- uspto-grants-2006_11
- 특허 번호
- US07138401B2
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