Diisopropylethylamine → HCID 21882826, 화합물

HRID 722136노트

반응식

HRID 722136 반응식
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[C:4]=1[CH2:10]Br.[C:12]1([N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:16][CH2:15][CH2:14][CH:13]=1.CCN(C(C)C)C(C)C>CC#N>[Br-:1].[F:9][C:5]1[C:4]2[CH2:10][CH:13]3[C:12](=[N+:17]4[CH2:21][CH2:20][CH2:19][CH2:18]4)[CH:16]([CH2:2][C:3]=2[CH:8]=[CH:7][CH:6]=1)[CH2:15][CH2:14]3

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 81570Pyrrolidine, 1-(1-cyclopenten-1-yl)-HCID 141116001,2-Bis(bromomethyl)-3-fluorobenzene

생성물 1

HCID 21882826HCID 21882826, 화합물수율 19.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

A solution of 1,2-bis-bromomethyl-3-fluoro-benzene (4.4 g, 15.6 mmol) in MeCN (10 ml) was added to stirred solution of 1-cyclopent-1-enyl-pyrrolidine (2.3 ml, 15.6 mmol) and DIPEA (5.4 ml, 31.2 mmol) in MeCN (20 ml). The mixture was stirred at room temperature for 18 hours and then filtered. Washing with cold MeCN afforded an off-white solid 1.02 g (19%). m/z 258 (M+).

후처리

  1. filtrationfiltered
  2. washWashing with cold MeCN

출처 및 근거

ORD 기록
ord-c1a7c274bb1e4c4b9fe095679e833898
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138400B2

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