Hydroxyamine hydrochloride → HCID 86591374, 화합물

HRID 722137노트

반응식

HRID 722137 반응식
[Br-].[F:2][C:3]1[C:4]2[CH2:5][CH:6]3[C:15](=[N+:16]4CCCC4)[CH:9]([CH2:10][C:11]=2[CH:12]=[CH:13][CH:14]=1)[CH2:8][CH2:7]3.Cl.NO.O.O.O.C([O-])(=[O:29])C.[Na+].C(O)C.O>O>[F:2][C:3]1[C:4]2[CH2:5][CH:6]3[C:15](=[N:16][OH:29])[CH:9]([CH2:10][C:11]=2[CH:12]=[CH:13][CH:14]=1)[CH2:8][CH2:7]3

참가 물질

6

반응물 4

HCID 443297Hydroxyamine hydrochlorideHCID 19096565Water ethanolHCID 21882826HCID 21882826, 화합물HCID 23665404Sodium Acetate Trihydrate

생성물 1

HCID 86591374HCID 86591374, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The product from Step 2 (1.02 g, 3.02 mmol), hydroxylamine hydrochloride (624 mg, 9.05 mmol) and sodium acetate trihydrate (1.23 g, 9.05 mmol) in 2:1 ethanol-water (12 ml) were heated to reflux and allowed to cool to room temperature, then stirred for 18 hours at this temperature. Water (10 ml) was added and the mixture filtered. The white solid was washed with water and dried under vacuum. 590 mg (89%). m/z 220 (M+H+).

후처리

  1. temperatureto reflux
  2. filtrationthe mixture filtered
  3. washThe white solid was washed with water
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-1b8657041d6a4dd0be665e472c1fa7d6
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138400B2

반응 노트

불러오는 중…