4-Bromoaniline → (3R)-N-(4-bromophenyl)-1-azabicyclo[2.2.2]octane-3-carboxamide

HRID 722176노트

반응식

HRID 722176 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([C:9]([OH:11])=O)[CH2:2]2.S(Cl)(Cl)=O.[Br:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1.C(N(CC)C(C)C)(C)C>CN(C=O)C>[Br:16][C:17]1[CH:23]=[CH:22][C:20]([NH:21][C:9]([C@@H:3]2[CH:4]3[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]3)[CH2:2]2)=[O:11])=[CH:19][CH:18]=1

참가 물질

6

반응물 4

HCID 78074-BromoanilineHCID 24386Thionyl ChlorideHCID 81531DiisopropylethylamineHCID 1380958(3R)-1-azabicyclo[2.2.2]octane-3-carboxylic acid

생성물 1

HCID 58742393(3R)-N-(4-bromophenyl)-1-azabicyclo[2.2.2]octane-3-carboxamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

9.17 g (about 47.8 mmol) of (R)-1-azabicyclo[2.2.2]octane-3-carboxylic acid are heated together with 160 ml of thionyl chloride under reflux for 1 h. The excess thionyl chloride is removed under reduced pressure, and residues are removed by azeotropic distillation together with toluene. The crude acid chloride obtained in this way is stirred together with 8.19 g (47.60 mmol) of 4-bromoaniline and 24.6 ml (190.4 mmol) of N,N-diisopropylethylamine in 59 ml of DMF at RT for 72 h. The solvent is removed under reduced pressure. The crude product is purified by chromatography on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol/triethylamine 70:30:2). The solvent is removed under reduced pressure. Finally, the last residues of solvent are removed under high vacuum. 5.5 g (37% of theory) of the title compound are obtained. The absolute configuration was assigned by crystal structure analysis of single crystals.

후처리

  1. temperatureunder reflux for 1 h
  2. customThe excess thionyl chloride is removed under reduced pressure, and residues
  3. customare removed by azeotropic distillation together with toluene
  4. customThe crude acid chloride obtained in this way
  5. customThe solvent is removed under reduced pressure
  6. customThe crude product is purified by chromatography on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol/triethylamine 70:30:2)
  7. customThe solvent is removed under reduced pressure
  8. customFinally, the last residues of solvent are removed under high vacuum

출처 및 근거

ORD 기록
ord-8ec25364b7574bffad86b86bc3731c1b
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138410B2

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