1-(3-fluoro-4-nitrophenyl)-1H-1,2,4-triazole → 2-Fluoro-4-(1,2,4-triazol-1-yl)phenylamine

HRID 722198

반응식

HRID 722198 반응식
[H][H].[F:3][C:4]1[CH:5]=[C:6]([N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)[CH:7]=[CH:8][C:9]=1[N+:10]([O-])=O>[Pd].O1CCCC1>[NH2:10][C:9]1[CH:8]=[CH:7][C:6]([N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)=[CH:5][C:4]=1[F:3]

참가 물질

5

반응물 2

HCID 218839191-(3-fluoro-4-nitrophenyl)-1H-1,2,4-triazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 218838662-Fluoro-4-(1,2,4-triazol-1-yl)phenylamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

Hydrogen was introduced under atmospheric pressure into the mixture consisting of 260 mg of 1-(3-fluoro-4-nitrophenyl)-1H-[1,2,4]triazole, 30 mg of Pd/C and 30 ml of tetrahydrofuran until the theoretical amount had been taken up. After filtering off the catalyst with suction and concentrating the mixture under reduced pressure, the remaining oily residue was purified by column chromatography (solvent: 98:2 dichloromethane:methanol; silica gel).

후처리

  1. filtrationAfter filtering off the catalyst with suction
  2. concentrationconcentrating the mixture under reduced pressure
  3. customthe remaining oily residue was purified by column chromatography (solvent: 98:2 dichloromethane:methanol; silica gel)

출처 및 근거

ORD 기록
ord-762ba5ff5a6e4357a88537fe8142c26b
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138414B2

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