2-(3-Methyl-5-(2-nitrophenyl)-4H-1,2,4-triazol-4-yl)benzoic acid → 2-[3-(2-Aminophenyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzoic acid

HRID 722207

반응식

HRID 722207 반응식
[CH3:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([OH:11])=[O:10])[C:5]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N+:22]([O-])=O)=[N:4][N:3]=1>O1CCCC1.[Pd]>[NH2:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[C:5]1[N:6]([C:7]2[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([OH:11])=[O:10])[C:2]([CH3:1])=[N:3][N:4]=1

참가 물질

4

반응물 1

HCID 218838872-(3-Methyl-5-(2-nitrophenyl)-4H-1,2,4-triazol-4-yl)benzoic acid

생성물 1

HCID 218838682-[3-(2-Aminophenyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzoic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

was prepared by hydrogenating 400 mg of 2-[3-methyl-5-(2-nitrophenyl)-[1,2,4]triazol-4-yl]benzoic acid in the presence of Pd/C in tetrahydrofuran and purified by stirring with dichloromethane.

후처리

  1. custompurified

출처 및 근거

ORD 기록
ord-197ab0f37be24bf0b716e4cde269af23
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138414B2

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