5-(3-Methoxy-4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one → 5-(4-Amino-3-methoxyphenyl)-1,3,4-oxadiazol-2(3H)-one

HRID 722215

반응식

HRID 722215 반응식
[H][H].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:14]2[O:18][C:17](=[O:19])[NH:16][N:15]=2)[CH:8]=[CH:9][C:10]=1[N+:11]([O-])=O>[Pd].C1COCC1>[NH2:11][C:10]1[CH:9]=[CH:8][C:7]([C:14]2[O:18][C:17](=[O:19])[NH:16][N:15]=2)=[CH:6][C:5]=1[O:4][CH3:3]

참가 물질

5

반응물 2

HCID 218839065-(3-Methoxy-4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 218838585-(4-Amino-3-methoxyphenyl)-1,3,4-oxadiazol-2(3H)-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

Hydrogen was introduced under atmospheric pressure into the mixture of 550 mg of 5-(3-methoxy-4-nitrophenyl)-3H-[1,3,4]oxadiazol-2-one, 100 mg of Pd/C and 50 ml of THF up to the theoretical uptake. Afterwards, the catalyst was filtered off with suction and the mixture was concentrated to dryness under reduced pressure.

후처리

  1. filtrationAfterwards, the catalyst was filtered off with suction
  2. concentrationthe mixture was concentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-d939b21e53a944c3aa5ddfdff4b7cc5a
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138414B2

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